
SAVING LIVES BY ELIMINATING HYPOXIC CANCER CELLS
Transforming cancer therapy by eliminating treatment-resistant cancer cells
Kripthonite Therapeutics is a Danish biotech company pioneering hypoxia-targeted cancer treatment. We are developing PH1154, a first-in-class compound designed to eliminate the hypoxic cancer cells that cause tumor relapse in patients with solid tumors.
We are currently in preclinical development, with strong in vivo efficacy data supporting our path toward clinical trials.

From research to real-world impact
Kripthonite Therapeutics grew out of pioneering research at Aarhus University, where Professor Thomas Poulsen's laboratory developed a new class of compounds with a unique ability to target hypoxic cancer cells. The background for this development was a family of naturally occuring molecules used as chemical warfare among bacteria in the seabed. Today, PH1154 lends it mechanism of action from these evolutionarily optimized molecules.
In 2023, we spun out from the university with the ambition to bring this science to patients. Our team combines deep scientific expertise with industry experience from large pharmaceutical companies and publically traded biotech companies focusing on hard-to-treat cancers.

Our journey
September 2025
Composition-of-matter patent granted by the USPTO
May 2025
Preseed investment from Marigold Maturation Fund
April 2023
Preclinical proof-of-concept of PH1154 as a hypoxia-targeted solid tumor therapy
January 2023
Kripthonite Therapeutics established as a spinout from Aarhus University
2021-2022
Prestigious soft funding for commercialization of academic research
January 2019
Proof-of-concept of first fully synthetic hypoxia-targeted macrocycle (HTMC)
The Team
Kripthonite is led by industry professionals and scientists with expertise spanning chemistry, cancer research, and pharmaceutical commercialization.
Join our mission
We are building a network of partners, collaborators, advisors, and investors who share our mission to improve cancer treatment. Reach out to learn more.





A gap in cancer treatment
Hypoxia is present in the majority of solid tumors, yet no existing therapy specifically targets hypoxic cancer cells. More than 3 million patients receive first-line radiotherapy each year, and for many, hypoxic cells limit treatment effectiveness and drive relapse.
Solving this problem could improve outcomes across virtually all solid tumor types. PH1154 is designed to do exactly that. Rather than replacing existing treatments, it works alongside radiotherapy, chemotherapy, and immunotherapy by killing hypoxic cancer cells that would otherwise not respond to therapy.









