SAVING LIVES BY ELIMINATING HYPOXIC CANCER CELLS

Transforming cancer therapy by eliminating treatment-resistant cancer cells

Kripthonite Therapeutics is a Danish biotech company pioneering hypoxia-targeted cancer treatment. We are developing PH1154, a first-in-class compound designed to eliminate the hypoxic cancer cells that cause tumor relapse in patients with solid tumors.

We are currently in preclinical development, with strong in vivo efficacy data supporting our path toward clinical trials.

Scientist wearing protective gear and blue gloves holding a glass slide with a pink specimen in a laboratory setting.

From research to real-world impact

Kripthonite Therapeutics grew out of pioneering research at Aarhus University, where Professor Thomas Poulsen's laboratory developed a new class of compounds with a unique ability to target hypoxic cancer cells. The background for this development was a family of naturally occuring molecules used as chemical warfare among bacteria in the seabed. Today, PH1154 lends it mechanism of action from these evolutionarily optimized molecules.

In 2023, we spun out from the university with the ambition to bring this science to patients. Our team combines deep scientific expertise with industry experience from large pharmaceutical companies and publically traded biotech companies focusing on hard-to-treat cancers.

Our journey

September 2025

Composition-of-matter patent granted by the USPTO

May 2025

Preseed investment from Marigold Maturation Fund

April 2023

Preclinical proof-of-concept of PH1154 as a hypoxia-targeted solid tumor therapy

January 2023

Kripthonite Therapeutics established as a spinout from Aarhus University

2021-2022

Prestigious soft funding for commercialization of academic research

January 2019

Proof-of-concept of first fully synthetic hypoxia-targeted macrocycle (HTMC)

The Team

Kripthonite is led by industry professionals and scientists with expertise spanning chemistry, cancer research, and pharmaceutical commercialization.

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Jan Stenvang

Chief Executive Officer

Management

Kristian Mark Jacobsen

Chief Scientific Officer

Board of Directors
Management

Per Hjerrild

Chief Technology Officer

Management
Board of Directors

Charlotte Dyring

Chief Operating Officer

Management

Søren Bregenholt

Chairman of the Board

Board of Directors

Erik Vinther

Member of the Board

Board of Directors

Thomas Poulsen

Co-founder and Chief Scientific Advisor - Medicinal Chemistry and In Vitro Biology

Advisory board
Board of Directors

Peter Horn Møller

Advisor in IPR strategy

Advisory board

Per thor Straten

Scientific Advisor - Immuno-Oncology

Advisory board

Michael R. Horsman

Scientific Advisor - Preclinical tumor hypoxia and radiotherapy models

Advisory board

Join our mission

We are building a network of partners, collaborators, advisors, and investors who share our mission to improve cancer treatment. Reach out to learn more.

Contact Kripthonite
Female scientist wearing safety goggles and gloves holding a test tube in a laboratory setting.
Tray of small laboratory sample tubes with blue caps on a white lab bench.

A gap in cancer treatment

Hypoxia is present in the majority of solid tumors, yet no existing therapy specifically targets hypoxic cancer cells. More than 3 million patients receive first-line radiotherapy each year, and for many, hypoxic cells limit treatment effectiveness and drive relapse.

Solving this problem could improve outcomes across virtually all solid tumor types. PH1154 is designed to do exactly that. Rather than replacing existing treatments, it works alongside radiotherapy, chemotherapy, and immunotherapy by killing hypoxic cancer cells that would otherwise not respond to therapy.